Special guidelines for the first batch of 26 major instruments in the 13th Five-Year Plan of 2016 were officially released

Last month, the 'Thirteenth Five-Year Development Plan' of the Natural Science Foundation of China (hereinafter referred to as the 'Plan') was officially released, clarifying the development strategies of 18 disciplines including life sciences and medicine in the next five years, as well as 8 science ministries and Priority development areas across the Ministry of Science. Among them, the Ministry of Life Sciences has identified 15 priority development areas, including the modification, interaction and activity regulation of biological macromolecules, the molecular mechanism of cell fate determination, the regulation mechanism of gametogenesis and embryonic development, and the cellular molecules of immune response and effect. Mechanism, steady-state regulation and functional mechanism of sugar/lipid metabolism, analysis of genetic law of important traits, formation and functional regulation of neural circuits, etc. The 'Plan' also clarified the 15 priority development areas of the Ministry of Medical Sciences, including the research on new common pathological mechanisms such as development, inflammation, metabolism, microecology, and microenvironment, as well as precision research on gene polymorphism, epigenetics, and diseases. Research on sudden infectious diseases, tumor complex molecular network, stem cell regulation and predictive intervention, research and prevention and control of chronic diseases such as cardiovascular and metabolic diseases, immune-related disease mechanisms and new immunotherapy strategies, reproduction-development-aging Frontier research on related diseases, etc. In addition, many of the 16 priority development areas of the inter-science department are related to biomedicine, including basic theories and new methods, new technologies in industry, medical imaging and image processing, dynamic modification of biological macromolecules and chemical interventions, and the realization of cell functions. System integration research, from the mechanism of aging to translational medicine research in geriatrics, and precision medicine research based on new models of disease data acquisition and integration. 'The 13th Five-Year Plan' first batch of 26 major project guidelines was officially released On July 8, the official website of the National Natural Science Foundation of China issued the 'Notice on Issuing the 'Thirteenth Five-Year' First Batch of Major Project Guidelines and Application Notes' ( Hereinafter referred to as 'Announcement'). The 'Notice' pointed out that the National Natural Science Foundation of China is now issuing the first batch of the '13th Five-Year Plan' on the basis of in-depth discussions and extensive solicitation of opinions from scientists based on the priority development areas of the '13th Five-Year Development Plan of the National Natural Science Foundation of China' Guide to 26 major projects. According to statistics, 5 of the 26 major projects in the first batch of the '13th Five-Year Plan' announced this time are related to the field of biomedicine. The major project of 'Molecular and Cellular Mechanisms of Metabolic Plasticity Regulation'Major projects.　　 The following is the specific content of the biomedical-related major project guidelines: 　　'Metabolites and cell-sensing metabolite abnormalities and tumor occurrence and development' Major project guidelines 　　Cell metabolism changes are one of the important characteristics of tumors. A large number of studies have found that tumor cells have undergone metabolic reprogramming, and the understanding of tumor metabolism is no longer limited to changes in glycolysis and tricarboxylic acid cycle. Many metabolic pathways include fatty acid metabolism, cholesterol metabolism, glutamine metabolism, and serine metabolism. , One-carbon unit metabolism, choline metabolism, etc., all have reprogramming changes in tumor cells. With the continuous deepening of tumor biology research, the research on the role of abnormal cell metabolism in tumorigenesis and development has become an active international academic frontier, and the theory that abnormal cell metabolism precedes tumorigenesis has gradually been confirmed in research.